A Global Overview on COVID-19 Pandemic: Vaccines and New Variants

Till August 25


INTRODUCTION
COVID-19 is a respiratory illness caused by the SARS-CoV-2 virus.Researchers around the globe are attempting to develop a vaccine.Till August 25, 2021, the world registered 213 million COVID-19 cases and 4.4 million mortalities were recorded globally (Figure 1).There are 139 total potential vaccines, currently, 42 potential vaccines are in their phase 3 clinical trials.So far, 22 vaccines have been approved in multiple countries 1 .The Pfizer-Bi-oNTech COVID-19 vaccine has been authorized by the Food and Drug Administration (FDA) for people aged 16 and above.However, it will be accessible for usage under emergency use for minors aged 12-15 and will now be sold under the brand name "Comirnaty".Dr. Janet Woodcock, acting FDA Commissioner stated in the organization's news release: "While millions of individuals have already received COVID-19 vaccinations successfully, we realize that the FDA approval of a vaccine may potentially inspire further confidence for being vaccinated among masses.Today's achievement brings us one step closer to changing the trajectory of the epidemic globally" 1,2 .This figure is highlighting the number of COVID-19 patients globally from January 2020 to August 2021.

DISCUSSION
The situation of COVID-19 pandemic and successes achieved in the development of COVID-19 vaccinations can be reviewed looking at an updated global perspective.

Can intradermal administration will increase COVID-19 vaccine doses?
COVID-19 vaccinations are being delivered intradermally (below the skin) in Thailand as the number of cases increases and vaccines become scarce.Intradermal injections need 25% less vaccine to generate the same degree of protection as compared to muscle injections 3 .AstraZeneca COVID-19 vaccines are manufactured in Thailand, and Thailand orders enough doses of other brands to immunize the country's population, but supplies are not delivered rapidly enough to Thais so that they may be able to get extra vaccines while they wait for their doses to come if intradermal delivery succeeds 4 .

Effectiveness of vaccine boosters on delta variant
Due to its increased transmissibility over previous strains, Delta has quickly become the prevalent strain in numerous nations, including Britain, India, and Pakistan.However, according to some reports: COVID-19 vaccines are less effective in preventing Delta strain.When asked whether the booster injections may assist in the containment of this virus Experts responded that they believe they can 5 .

Moderna for minors (aged 12-17) approved in the United Kingdom (UK)
Moderna has been licensed by the UK's Medicines and Healthcare Products Regulatory Agency (MHRA) for people aged 12-17.Dr. June Raine, the MHRA's chief executive, writes in a government news release: "It is with great pleasure, I confirm that the COVID-19 vaccine manufactured by Moderna has now been approved for use in children aged 12 to 17 years.For this age range, the vaccination is both safe and efficacious" 1,5,6 .

Can pregnant women get COVID-19 vaccine jabs? CDC updates
According to the Centers for Disease Control and Prevention (CDC), COVID-19 vaccination is safe for pregnant women and negates erroneous allegations that the injections cause infertility or miscarriages.The source had been updated to include new evidence on the safety of mRNA vaccines (Pfizer-BioNTech or Moderna) that showed no increased risk of miscarriage in women who had taken at least one dose of vaccine before 20 weeks.In an interview with NBC News, CDC Director Dr. Rochelle Walensky said, "The CDC strongly urges all pregnant women or those who are considering pregnancy, as well as those who are nursing, to receive vaccines" 7 .
Nevertheless, because of the highly transmissible Delta variant as well as COVID-19's devastating effects on unvaccinated pregnant women, it has never been more important to promote immunizations.As a result of the extremely contagious Delta form of COVID-19, the United States, India, and Brazil are now dealing with an upsurge in the hospitals, and health authorities also noticed several pregnant women who have become victimized by the disease in the past few weeks.However, according to the Centers for Disease Control and Prevention (CDC), approximately only 23% of pregnant women have gotten even one dosage of the COVID-19 vaccines.In any way, vaccines, including the COVID-19 vaccines, do not increase the risk of infertility in men or women 8 .

FDA to approve vaccine boosters for immunocompromised people
According to recent resources, FDA is reportedly ready to approve the delivery of extra COVID-19 vaccine booster injections for immunocompromised patients.During the next couple of weeks, the FDA will evaluate relevant data from CDC.As part of the study, researchers will explore if an extra booster injection might assist increase protection against COVID-19 in those who are clinically immunocompromised 9 .Sputnik V to be effective 83% against delta strain of COVID-19: says Health Minister Despite lower levels of protection, the Sputnik V COVID-19 vaccine produced by Russia appears to be extremely efficient against SARS-Delta CoV-2's strain.Russian Health Minister Mikhail Murashko stated that the Gam-COVID-Vac injection, also known as Sputnik V, was about 83% effective against the Delta strain, which currently accounts for more than 90% of new infections.Russian news outlet Telegraph Agency of the Soviet Union (TASS) claimed that the vaccine's effectiveness against serious illness also exceeds 95%.Before this, the vaccine's researchers predicted that the injection would have a 90% efficiency.In phase 3 clinical trials, researchers find out that the vaccine was approximately 92% effective against the original strain of the coronavirus.Sputnik V has been authorized by 67 nations, including India, Brazil, the Philippines, and Turkey.In addition, Germany also plans to purchase up to 30 million doses of the vaccine after it is approved by the European Medicines Agency (EMA) 1,9 .

Is the second dose of mRNA vaccine being safe after an allergic response from the first dose?
An estimated 2% of individuals experienced adverse side-effects from mRNA COVID-19 vaccinations, such as the Pfizer-BioNTech and Moderna vaccines.The great majority of these responses are mild.A new study article published in the Journal of American Medical Association examined how these people responded to their second dosage.The study included information from 159 people who experienced an adverse reaction from their first dose of mRNA vaccination and then received a second dose 7 .
According to the study, 47/159 individuals took an antihistamine before the second dosage."All 159 patients, including 19 with first-dose anaphylaxis, tolerated the second dose.Thirty-two (20%) patients had acute and possibly allergic symptoms associated with the second dosage that was self-limited, mild, and/or alleviated with antihistamines alone" 2,6 .

Hesitation towards COVID-19 vaccine jabs among low-and middle-income countries
According to a new study published in the journal 'Nature Medicine', populations from low-and middle-income countries (LMICs) had less COVID-19 vaccination reluctance than those from high-income nations.In addition to this, seven studies were conducted in low-income countries (Sierra Leone, Burkina Faso, Rwanda, Uganda, and Mozambique) five studies were undertaken in nations with a lower-middle-income level (India, Pakistan, Nepal, and Nigeria) and one study was done in middle-income country (Colombia).According to the data, the average vaccination acceptance rate in LMICs was 80.3%.They also demonstrated that even the LMICs with the lowest rates -Burkina Faso and Pakistan -performed better in terms of COVID-19 vaccine uptake than Russia and the United States.Vaccine uptake rates were 66.5% in both Burkina Faso and Pakistan 10 .Ironically, the digits were 64.6% in the United States and 30.4% in Russia.Dr. Alexandra Scacco, a senior research fellow at the WZB Berlin Social Science Center and co-author of the study, observed that "Across nations, we see that adoption of COVID-19 vaccines is typically somewhat diverse, it may be due to their novelty" 11 .

What do we need to know about DNA vaccines?
The field of medicine continues to see radical new techniques for combating COVID-19, with the most recent development being in vaccination 12 .India has approved the world's first DNA vaccine for use in an emergency against COVID-19, joining almost a dozen additional DNA vaccine candidates in clinical testing 13 .The ZyCoV-D vaccine works by priming the immune system against the virus that causes COVID-19, SARS-CoV-2.It is also administered without the use of an injection 14 .This vaccine differs from the messenger RNA (mRNA) technology utilized in two of the currently approved COVID-19 vaccines, Moderna and Pfizer-BioNTech, both of which have received praise for their inventiveness 14 .
Table 1 highlights the concerns about the COVID-19 pandemic globally.It mentions the number of COVID-19 cases and mortalities, it further highlights the mass vaccination process which has started globally.This table also gives information about serious concerns of people regarding the administration of COVID-19 vaccinations in people who are pregnant, immunocompromised, and allergic.One of the most important social issues has also been discussed in this table about the acceptance of vaccines in certain nations.

CONCLUSION
Coronavirus is declared a pandemic by WHO in the previous year.Since its inception health pantheons and several big Whig pharmaceutical companies striving best to contain this virus by implementing a plethora of preventive measures and developing COVID-19 vaccines.So far, many vaccines have been developed and their results are very promising.Hitherto, scientists have achieved marvelous results regarding these vaccines such as these vaccines are safe for younger people, pregnant and lactating women, immunocompromised people.Furthermore, vaccine boosters are also efficacious against the deadliest strains of COVID-19 such as Delta, Epsilon, Beta, and Alpha.Now people across the globe are trusting these vaccines and voluntarily administering them.