DIAGNOSIS OF RETINOBLASTOMA IN CHILDREN

ABSTRACT

Background:

The purpose of this study is to assess radiological features (CT and Ultrasound) of retinoblastoma in clinically susceptible patients.
Methods: This study has been conducted at Jinnah Medical College and Hospital from January 2016 to January 2017. 39 children with clinical diagnosis of retinoblastoma referred from Layton Rahmatulla Benevolent Trust (LRBT) Eye hospital and by other eye clinics to Jinnah Medical College and Hospital Karachi. Ultrasound and CT scan of orbit of all children under the age 5 years was performed to see local tumor extent and associated intracranial primitive neuroectodermal tumor (trilateral retinoblastoma).

Results:

Out of 39 children with clinically suspected to have retinoblastoma, of these 32 were male and 7 were female children. Mean age of patients was 2.5 years. Out of 39, only 25 children had unilateral and 14 had bilateral intraocular tumor on ultrasound and CT scan. It appeared as a heterogenous mass with areas of calcification and retro- orbital extension, was better seen on CT images. Ultrasound of orbits showed calcification in only 29 children out of 39. Only 3 children found to have trilateral retinoblastoma. Ultrasound was found to bediagnostic but CT showed better results for imagining and diagnosis of retinoblastoma (unilateral, bilateral).

Conclusion:

This study shows that CT scan, is more accurate for the assessment of tumor size, localization and retro-orbital and intracranial extension of the retinoblastoma rather than other modalities. Thus CT scan, found to be affective in diagnosis, planning treatment and determining the prognosis of this disease.

Key words:

Retinoblastoma, Leukocoria, CT scan, Doppler Ultrasound.

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